Endocrine abnormalities in children with Beta thalassaemia major
نویسندگان
چکیده
منابع مشابه
Endocrine complications in patients with thalassaemia major
Patients with multi-transfused thalassaemia major may develop severe endocrine complications due to iron overload. The anterior pituitary is particularly sensitive to iron overload which disrupts hormonal secretion resulting in hypogonadism, short stature , acquired hypothyroidism and hypoparathyroidism. Glucose intolerance and diabetes mellitus are also common in thalassaemic patients. The sev...
متن کاملEndocrine Disorders in Beta thalassemia Major Patients
Background Thalassemia is the most common hereditary disorder worldwide. The patient's’ survival is dependent on lifetime blood transfusion which leads to iron overload and its toxicity on various organs including endocrine glands. The study aimed to investigate endocrine disorders in patients with Beta-thalassemia major in the Southern Khorasan province, Iran. Materials and Methods In this des...
متن کاملReproductive behaviour of mothers of children with beta-thalassaemia major.
Thalassaemia is the most common monogenic autosomal hereditary disease worldwide. This questionnaire-based cross-sectional study looked at the reproductive behaviour of 156 mothers of children affected with beta-thalassaemia major (Cooley anaemia) in Fars province, southern Islamic Republic of Iran. Regardless of the number of affected children, the parents of children with Cooley anaemia had a...
متن کاملPolytransfused children with beta thalassemia major have wider endocrine dysfunction.
INDIAN PEDIATRICS 843 VOLUME 42AUGUST 17, 2005 We read with interest the brief report entitled “Assessment of adrenal endocrine function in Asian Thalassemics”(1). A large number of children in India undergo long term transfusions and are therefore at risk of hypothalamo-pituitary dysfunction. The paper makes an important observation of detecting biochemical evidence of adrenal hypofunction in ...
متن کاملPlatelet function in beta-thalassaemia major.
Abnormal platelet aggregation was found in eight (44%) of 18 patients with beta-thalassaemia major and transfusional iron overload. The aggregation defect bore no correlation with the degree of hepatic fibrosis, liver function tests, whether or not splenectomy had been performed, the degree of iron overload, haematocrit, platelet count, serum vitamin E level, or leucocyte ascorbate concentratio...
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ژورنال
عنوان ژورنال: Sri Lanka Journal of Child Health
سال: 2013
ISSN: 2386-110X,1391-5452
DOI: 10.4038/sljch.v42i2.5628